Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science

Till the 21st century, fatty acids were considered as merely building blocks for triglycerides, phospholipids, or cholesteryl esters. However, discovery of G protein-coupled receptors (GPCRs) free at beginning century challenged that idea and paved way a new field research, merged into receptor pharmacology intercellular lipid mediators. Among GPCRs acids, acid 4 (FFA4, also known GPR120) recognizes long-chain polyunsaturated such DHA EPA. It is significant in drug because it regulates obesity-induced metaflammation GLP-1 secretion. Our study reviews information on newly developed FFA4 agonists their application pathophysiologic studies discovery. offers potency comparison an AP-TGF-α shedding assay.